Biochemistry, Molecular Biology, and Physiology of Phospholipase A2 and Its Regulatory Factors

by Anil B. Mukherjee

Publisher: Springer

Written in English
Published: Pages: 272 Downloads: 290
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Subjects:

  • Biochemistry,
  • Lipolytic Enzymes,
  • Science,
  • Science/Mathematics,
  • Life Sciences - Botany,
  • Life Sciences - Zoology - General,
  • Science / Biochemistry,
  • Life Sciences - Biochemistry,
  • Congresses,
  • Inhibitors,
  • Mechanism of action,
  • Phospholipase A2,
  • Phospholipases

Edition Notes

Advances in Experimental Medicine and Biology

The Physical Object
FormatHardcover
Number of Pages272
ID Numbers
Open LibraryOL10324351M
ISBN 10030643699X
ISBN 109780306436994

Phospholipase A2, group XVI (PLA2G16) is a thiol hydrolase from the HRASLS family that regulates lipolysis in adipose tissue and has been identified as a host factor enabling the cellular entry of picornaviruses. Chemical tools are essential to visualize and control PLA2G16 activity, but they have not been reported to date. Here, we show that MB, which is a fluorescent lipase probe, also Cited by: 4. Phospholipases A2 (PLA2s) EC are enzymes that cleave fatty acid in position two of phospholipids, hydrolyzing the bond between the second fatty acid “tail” and the glycerol molecule. This particular phospholipase specifically recognizes the sn-2 acyl bond of phospholipids and catalytically hydrolyzes the bond, releasing arachidonic acid and lysophosphatidic : BRENDA entry. Since the identification of fat-soluble A a century ago (), retinoids (vitamin A and its natural and synthetic analogs) have been the most extensively studied of the fat-soluble research has identified essential roles for retinoids in many different aspects of mammalian physiology, including embryonic development, adult growth and development, maintenance of immunity, maintenance Cited by: Regulatory Functions of Phospholipase A2 Article. Recent advances in molecular and cellular biology have enabled us to understand the molecular nature, possible function, and regulation of a.

USA Home > Product Directory > Biochemicals and Reagents > Enzymes, Inhibitors, and Substrates > Enzyme Substrates > Substrates by Enzyme > Phospholipase A2 . the calcium-independent phospholipase A 2 (iPLA 2) is a predominant phospholipase A 2 activity present in myocardium and is selective for arachidonylated plasmalogen substrates (5,12).Furthermore, iPLA 2 is rapidly activated after global ischemia ().We recently demonstrated the activation of cAMP-dependent protein kinase (PKA) by lysoplasmenylcholine, an enzymic product of iPLA 2-mediated Cited by: Vades P, et al. Characterization of extra cellular phospholipase A2 in human synovial fluids. Life Sci Vades P, et al. Soluble phospholipase A2 in human pathology: clinical-laboratory interface. Biochemistry, molecular biology, and physiology of phospholipase A2 and its regulatory factors. Ed. AB Mukherjee, Plenum Press, New York. The phospholipase A2 superfamily and its group numbering system. Biochim Biophys Acta –, Biochemistry and Molecular Biology of Fishes, edited by Hochachka P and Mommsen T. New York: Elsevier, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. , No. 4.

IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), Vol. 58, No. Molecular mechanisms underlying inflammatory lung diseases in the elderly: Development of a novel therapeutic strategy for acute lung injury and pulmonary fibrosisCited by: 58 Crowl R, Stoner C, Stoller T, Pan Y-C, Conroy R. Isolation and characterization of cDNA clones from human placenta coding for phospholipase A2. In: Mukherjee AB, ed. Biochemistry, Molecular Biology, and Physiology of Phospholipase A2 and its Regulatory Factors. New York, NY: Plenum Press; Google Scholar; 59 Wight TN. The Cited by: Many of phospholipase D’s cellular functions are mediated by its principal product, phosphatidic acid (PA). PA is a negatively charged phospholipid, whose small head group promotes membrane curvature. It is thus thought to facilitate membrane-vesicle fusion and fission in a manner analogous to clathrin-mediated endocytosis. PA may also recruit proteins that contain its corresponding binding InterPro: IPR Get this from a library! Auxin Molecular Biology. [Catherine Perrot-Rechenmann; Gretchen Hagen] -- The plant hormone auxin plays a fundamental role in the growth and development of plants. Researchers from across the globe are currently attempting to unravel the molecular mechanisms by which auxin.

Biochemistry, Molecular Biology, and Physiology of Phospholipase A2 and Its Regulatory Factors by Anil B. Mukherjee Download PDF EPUB FB2

Biochemistry, Molecular Biology, and Physiology of Phospholipase A2 and Its Regulatory Factors. Editors: Mukherjee, Anil B. Biochemistry Free Preview. During the past decade there has been a dramatic expansion of our knowledge on phospholipases in general, and phospholipase A2 (PLA2) in particular.

Progress in this field has been evident on many fronts, with novel information rapidly accumulating in the literature regarding the chemistry and molecular biology of this enzyme and its role in. Adv Exp Med Biol. ; Biochemistry, molecular biology, and physiology of phospholipase A2 and its regulatory factors.

[No authors listed]. Biochemistry, molecular biology, and physiology of phospholipase A₂ and its regulatory factors. [Anil B Mukherjee;] -- Proceedings of a symposium in Bethesda, Maryland, Septemberwhich focused on the enzyme phospholipase A2, associated with cellular signal transduction, and the generation of many cellular.

"Proceedings of a symposium on Biochemistry, molecular biology, and physiology of phospholipase A₂ and its regulatory factors, held Sept.in Bethesda, Maryland"--Title page verso.

Description: 1 online resource (viii, pages): illustrations (some color) Contents: Phospholipases, Enzymes That Share a Substrate Class In: Mukherjee A.B. (eds) Biochemistry, Molecular Biology, and Physiology of Phospholipase A2 and Its Regulatory Factors. Advances in Experimental Medicine and Biology, vol Springer, Boston, MACited by: 8.

M.H.Z. Labib, B.J.M. Jones, in Scientific Foundations of Biochemistry in Clinical Practice (Second Edition), Serum Phospholipase A Phospholipase A 2 is produced in the pancreas in the form of its inactive precursor, prophospholipase A 2, which is activated to phospholipase A 2 by trypsin and other proteolytic enzymes when secreted into the duodenum.

Phospholipase A2 Biochemistry. Molecular basis of phospholipase A2 activity toward phospho- of cytosolic phospholipase A2, a regulatory Ca(2+)-dependent. Abstract. The phospholipase A 2 enzymes are important components of the cellular machinery that responds to inflammatory stimuli and maintains cell homeostasis by membrane remodelling.

Their role as the rate-limiting step in the production of pro-inflammatory lipid mediators makes these enzymes an important therapeutic target for the treatment Cited by: The phospholipases (PLs) make up a very diverse group of enzymes that share the common action of catalyzing hydrolysis of phospholipids.

Phospholipases A hydrolyze the carboxylic esters at the sn-1 (phospholipase A1) or sn-2 (phospholipase A2; PLA 2) positions of glycerol backbones. AB Mukherjee (Ed.), Biochemistry, molecular biology and physiology of phospholipase A 2 and its regulatory factors, Advances in Experimental Medicine and Biology Cited by: Abstract.

The phospholipase A 2 (PLA 2) superfamily consists of many different groups of enzymes that catalyze the hydrolysis of the sn-2 ester bond in a variety of different phospholipids.

The products of this reaction, a free fatty acid, and lysophospholipid have many different important physiological by: In: Mukherjee A.B. (eds) Biochemistry, Molecular Biology, and Physiology of Phospholipase A2 and Its Regulatory Factors.

Advances in Experimental Medicine and Biology, vol Springer, Boston, MACited by: 5. Hirata F., Hirata A. () Biology of Phospholipase Inhibitory Proteins. In: Mukherjee A.B. (eds) Biochemistry, Molecular Biology, and Physiology of Phospholipase A2 and Its Regulatory Factors. Advances in Experimental Medicine and Biology, vol Cited by: 7.

Phospholipase A2 in Clinical Inflammation presents an up-to-date topical review of the biochemistry, molecular biology, and biology of mammalian phospholipase A2 (PLA2). The emphasis of this monograph is on the current aspects of PLA2 research using molecular approaches to investigate PLA2 structure and function, inhibitor design, and the.

FRYE, G. FRIOU, in Leukocyte Membrane Determinants Regulating Immune Reactivity, Publisher Summary. This chapter discusses enzyme phospholipase A (PLA) for the molecular basis of killing in K cell cytotoxic reactions.

An effector cell-bound location for such an enzyme would be predicted on the grounds that soluble enzyme is incapable of attacking native plasma membrane phospholipid. Biochemistry and Physiology of Polymines in Plants: Solcum, Robert D & Hector E Flores eds: P Biochemistry Molecular Biology and Physiology of Phospholipase A2 and its Regulatory Factors: Mukherjee, Anil B ed: EUR Biochemistry of Foods 3rd edn (PB) Eskin, N A Michael & Fereidoon Shahidi: Rs Biochemistry.

Abstract. From the point of view of protein structure and catalytic mechanism, phospholipases A 2 (PLA 2 ’s) are among the best characterized enzymes. Most of what is known about the structure and enzymology of PLA 2 is based on studies using the enzymes purified Cited by: Author(s): Mukherjee,Anil B Title(s): Biochemistry, molecular biology, and physiology of phospholipase A2 and its regulatory factors/ edited by Anil B.

Mukherjee. Country of Publication: United States Publisher: New York: Plenum Press, c The phospholipase A2 enzymes are important components of the cellular machinery that responds to inflammatory stimuli and maintains cell homeostasis by membrane remodelling.

Their role as the rate-limiting step in the production of pro-inflammatory lipid mediators makes these enzymes an important therapeutic target for the treatment of inflammatory by: Plant Phospholipase A: Advances in molecular biology, biochemistry and cellular function Article Literature Review in Biomolecular concepts July with 58 Reads How we measure 'reads'.

Biochemistry, Molecular Biology, and Physiology of Phospholipase A2 and Its Regulatory Factors Anil B Mukherjee The NATO-Advanced Research Workshop "Esterases, Lipases and Phospholipases: From Structure to Clinical Significance" was held at the University of Bordeaux II, France from 22nd- 24th September under the Directorship of.

Phospholipase A2 (PLA2) designates a class of enzymes that hydrolyze the sn-2 ester of glycerophospholipids to produce a fatty acid and a lysophospholipid. It has become clear that some of these enzymes liberate arachidonic acid in mammalian cells for the biosynthesis of eicosanoids, and thus there has been considerable interest in developing PLA2 inhibitors.

National Institute of Child Health and Human Development (U.S.) Title(s): Biochemistry, molecular biology, and physiology of phospholipase A2 and its regulatory factors[graphic] Country of Publication: United States Publisher: [Bethesda, Md.: Medical Arts and Photography Branch, National Institutes of Health, ] Description: 1.

Insulin-like growth factors (IGFs) are potent stimulators of cellular growth and their half-life and biological activity are regulated by specific IGF binding proteins (IGFBPs). Western ligand blots of non-reduced human, bovine, ovine and porcine sera reveal an. Buy The Phospholipase C Pathway: Its Regulation and Desensitization (Molecular Biology Intelligence Unit) on FREE SHIPPING on qualified orders.

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II). "Release and Function of Phospholipase A2 from Inflammatory Cells" organized by Dr. Patrick Wong and Dr. Edward Dennis at the FASEB meeting in New Orleans (Ma ). Readers will find exciting advances in our understanding of the structure, function and molecular biology of phospholipase A2 research which is presented in this by: 3.

Biochemistry Molecular Biology and Physiology of Phospholipase A2 and its Regulatory Factors: Mukherjee, Anil B ed: EUR BIODIGESTER: An Innovative Technology for on-board Disposal of Human Waste in Indian Railways: Singh, Lokendra & Vrat Kamboj: Rs Biological Sciences: Innovations and Dynamics: Sinha, Rajeshwar P et.

Phospholipase A2 enzymes (PLA2 enzymes) are the most fascinating group of proteins and Venom Phospholipase A2 Enzymes is the first comprehensive book covering both fundamental and recent advances in phospholipase research.

Particular emphasis is placed on the pharmalogical effects of snake venom PLA2 : R. Manjunatha Kini. `The book is a must for all scientists in plant lipid research and a valuable source of information for plant physiologists, biochemists and plant molecular biologists.

' Journal of Plant Physiology, ` The volume is addressed to scientists and PhDstudents, actively involved in a lipid research.Molecular Structure of Phospholipase D and Regulatory Mechanisms of Its Activity in Plant and Animal Cells Y.

S. Kolesnikov 1, K. P. Nokhrina 2, S. V. Kretynin 1, I. D. Volotovski 3,Cited by:   Read "Inhibition of secretory phospholipase A2 enzyme by bilirubin: A new role as endogenous anti-inflammatory molecule, Molecular and Cellular Biochemistry" on DeepDyve, the largest online rental service for scholarly research with thousands of .